Use CO2 cartridges only in emergency situations. Never use the C02 cartridge to regularly inflate your tires, once tires are inflated with a C02 unit air, air will dissipate through your tire. you will notice a noticeable loss of air overnight having used the C02 cartridge. If you do use a co2 cartridge, I would then deflate the tire and refill tire as your normally would do once you get to a safe spot.